Skip to content
Our Mission
Our Team
Intrathecal Drug Delivery
Neuropathologies
Publications
Contact
Our Mission
Our Team
Intrathecal Drug Delivery
Neuropathologies
Publications
Contact
Publications
On reduced-order modeling of drug dispersion in the spinal canal
F.J. Parras, A.L. Sánchez, C. Martínez-Bazán, W. Coenen, C. Gutiérrez-Montes
Fluids and Barriers of the CNS 22 66 (2025)
https://doi.org/10.1186/s12987-025-00657-6
Arterial pulsations and transmantle pressure synergetically drive glymphatic flow
G. Nozaleda, W. Coenen, V. Haughton, A.L. Sánchez
Scientific Reports 15 13798 (2025)
https://www.nature.com/articles/s41598-025-97631-x
Direct numerical simulation of the global transition in laminar low-density axisymmetric jets
D. Gómez-Lendinez, W. Coenen, A. Sevilla
International Journal of Heat and Mass Transfer 229 125651 (2024)
https://doi.org/10.1016/j.ijheatmasstransfer.2024.125651
Effects of buoyancy on the dispersion of drugs released intrathecally in the spinal canal
J. Alaminos-Quesada, C. Gutiérrez-Montes, W. Coenen, A.L. Sánchez
Journal of Fluid Mechanics 985 A20 (2024)
https://doi.org/10.1017/jfm.2024.297
Floquet stability analysis of a two-layer oscillatory flow near a flexible wall
A. Barcenas-Luque, W. Coenen, C. Gutiérrez-Montes, C. Martinez-Bazan
Journal of Fluid Mechanics 978 A24 (2023)
https://doi.org/10.1017/jfm.2023.1026
An analytic model for the flow induced in syringomyelia cysts
G. Nozaleda, J. Alaminos-Quesada, W. Coenen, V. Haughton, A.L. Sánchez
Journal of Fluid Mechanics 978 A22 (2023)
https://doi.org/10.1017/jfm.2023.1018
Stationary flow driven by non-sinusoidal time-periodic pressure gradients in wavy-walled channels
J. Alaminos-Quesada, C. Gutiérrez-Montes, W. Coenen, A.L. Sánchez
Applied Mathematical Modelling 122 693--705 (2023)
https://doi.org/10.1016/j.apm.2023.06.013
In vitro characterization of solute transport in the spinal canal
F. Moral-Pulido, J.I. Jiménez-González, C. Gutiérrez-Montes, W. Coenen, A.L. Sánchez & C. Martínez-Bazán
Physics of Fluids 35, 051905 (2023)
https://doi.org/10.1063/5.0150
Oscillating viscous flow past a streamwise linear array of circular cylinders
J. Alaminos-Quesada, J.J. Lawrence, W. Coenen & A.L. Sánchez
Journal of Fluid Mechanics 959 A39 (2023)
https://doi.org/10.1017/jfm.2023.178
Buoyancy-modulated Lagrangian drift in wavy-walled vertical channels as a model problem to understand drug dispersion in the spinal canal
J. Alaminos-Quesada, W. Coenen, C. Gutierrez-Montes, & A.L. Sánchez
Journal of Fluid Mechanics 949 A48 (2022)
https://doi.org/10.1017/jfm.2022.799
Effect of Normal Breathing on the Movement of CSF in the Spinal Subarachnoid Space
C. Gutiérrez-Montes, W. Coenen, M. Vidorreta. S. Sincomb, C. Martínez-Bazán, A.L. Sánchez & V. Haughton
American Journal of Neuroradiology 44 (9) 1369-1374 (2022)
https://doi.org/10.3174/ajnr.A7603
A one-dimensional model for the pulsating flow of cerebrospinal fluid in the spinal canal
S. Sincomb, W. Coenen, C. Gutierrez-Montes, C. Martínez-Bazán, V. Haughton & A.L. Sánchez
Journal of Fluid Mechanics 939 A26 (2022)
https://doi.org/10.1017/jfm.2022.215
Transmantle Pressure Computed from MR Imaging Measurements of Aqueduct Flow and Dimensions
S.J. Sincomb, W. Coenen, E. Criado-Hidalgo, K. Wei, K. King, M. Borzage, V. Haughton, A.L. Sánchez & J.C. Lasheras
American Journal of Neuroradiology 42 (10) 1815-1821 (2021)
https://doi.org/10.3174/ajnr.A7246
Transmantle Pressure Computed from MR Imaging Measurements of Aqueduct Flow and Dimensions
S.J. Sincomb, W. Coenen, E. Criado-Hidalgo, K. Wei, K. King, M. Borzage, V. Haughton, A.L. Sánchez & J.C. Lasheras
American Journal of Neuroradiology 42 (10) 1815-1821 (2021)
https://doi.org/10.3174/ajnr.A7246
Lubrication analysis of peristaltic motion in non-axisymmetric annular tubes
W. Coenen, X. Zhang & A.L. Sánchez
Journal of Fluid Mechanics 921 R2 (2021
https://doi.org/10.1017/jfm.2021.525
Modelling and direct numerical simulation of flow and solute dispersion in the spinal subarachnoid space
C. Gutiérrez-Montes, W. Coenen, J.J. Lawrence, C. Martínez-Bazán, A.L. Sánchez & J.C. Lasheras
Applied Mathematical Modelling 94 516--533 (2021)
https://doi.org/10.1016/j.apm.2021.01.037
A model for the oscillatory flow in the cerebral aqueduct
S. Sincomb, W. Coenen, A.L. Sánchez & J.C. Lasheras
Journal of Fluid Mechanics 899 R1-1--12 (2020)
https://doi.org/10.1017/jfm.2020.463
Subject-specific evaluation of CSF bulk flow in the spinal canal: recirculating flow patterns and implications for ITDD
W. Coenen, C. Gutiérrez-Montes, S. Sincomb, E. Criado-Hidalgo, C. Martínez-Bazán, K. King, V. Haughton, A.L. Sánchez & J.C. Lasheras
American Journal of Neuroradiology 40 (7) 1242--1249 (2019
https://doi.org/10.3174/ajnr.A6097
On the dispersion of a drug delivered intrathecally in the spinal canal
J.J. Lawrence, W. Coenen, A.L. Sánchez, G. Pawlak, C. Martínez-Bazán, V. Haughton & J.C. Lasheras
Journal of Fluid Mechanics 861 679--720 (2019)
https://doi.org/10.1017/jfm.2018.937